GaMEG lab is a research group leaded by dr. Marcin Magierowski, focused on the physiology, pathophysiology and pharmacology of gastrointestinal (GI) tract and GI disorders. We are especially interested in the possible implementation of endogenous gaseous mediators-releasing compounds into the GI pharmacology. We work on experimental in vitro and in vivo models using human-derived cell lines and laboratory animals. GaMEG lab is also establishing collaboration with clinically-oriented departments within Jagiellonian University.

GaMEG lab is settled in the Department of Physiology, Jagiellonian University Medical College. GaMEG lab fully covers Cellular Engineering and Isotope Diagnostics Lab (pol. Pracownia Inżynierii Komórkowej i Diagnostyki Izotopowej) with the Genetic Engineering Laboratory (GMM, class II) status and lab-animal facility located at the Department of Physiology, crucial for our scientific activity.

GaMEG lab is/has been involved in few research grants:

1. Endogenous carbon monoxide (CO) and novel CO-releasing prodrugs in pathophysiology and pharmacology of esophageal metaplasia development; sponsored by National Science Centre in Poland (2019/33/B/NZ4/00616 (OPUS)); budget: approx. 2 350 000 PLN; scientific partners: i) Prof. Binghe Wang, Georgia State University (Atlanta, USA), ii) Laboratory of Gastroenterology and Hepatology, Erasmus MC (The Netherlands); duration: 2020-present; PI: dr. Marcin Magierowski
2. Modulation of molecular pathways by pharmacological mitochondria-targeting hydrogen sulfide donor in chronic gastric ulcer healing process; sponsored by National Science Centre in Poland (2020/37/N/NZ4/04192 (PRELUDIUM)); budget: approx. 210 000 PLN; scientific partner: Prof. Matthew Whiteman, University of Exeter (The United Kingdom); duration: 2021-present, PI: dr. Dagmara Wójcik, Supervisor: dr. Marcin Magierowski
3. The role of the physical exercise and skeletal muscle-adipose tissue crosstalk in the development of experimental Barrett’s esophagus and esophageal adenocarcinoma; sponsored by National Science Centre in Poland (2020/37/B/NZ4/03454 (OPUS)); budget: approx. 2 200 000 PLN; duration: 2021-present, PI: Prof. Tomasz Brzozowski
4. Novel hydrogen sulfide-releasing derivatives of non-steroidal anti-inflammatory drugs in the treatment and prevention of esophageal mucosa disorders; sponsored by The National Center for Research and Development (0055/L-8/2016 (LIDER)); budget: approx. 1 200 000 PLN; bussiness partner: Antibe Therapeutics Inc., Toronto (Canada); duration: 2018- present; PI: dr. Marcin Magierowski
5. Hydrogen sulfide as endogenous protective molecule in pathophysiology of Barrett’s esophagus development; sponsored by National Science Centre in Poland (2014/15/N/NZ4/04564 (SONATA)); budget: approx. 850 000 PLN; scientific partner: Laboratory of Gastroenterology and Hepatology, Erasmus MC (The Netherlands); duration: 2017-present; PI: dr. Marcin Magierowski
6. The influence of bariatric surgery procedures and vagotomy on changes to the secretion of gastrointestinal hormones associated with obesity and the degree of weight loss – an animal model experimental study; sponsored by National Science Centre in Poland (2016/23/N/NZ4/03252 (PRELUDIUM)); budget: approx. 50 000 PLN; duration: 2017-present; PI: dr. Mateusz Wierdak
7. Involvement of carbon monoxide (CO) in gastroprotection against experimental ischemia/reperfusion-induced gastric erosions; sponsored by National Science Centre in Poland (2016/23/N/NZ4/01890 (PRELUDIUM));  budget: approx. 50 000 PLN; duration: 2017-present; PI: dr. Katarzyna Magierowska
8. Role of mesenteric white adipose tissue and muscle-fat crosstalk on severity of experimental colitis in mice; sponsored by National Science Centre in Poland (2013/09/B/NZ4/01566 (OPUS)); budget: approx. 600 000 PLN; duration: 2014-2018; PI: Prof. Tomasz Brzozowski
9. Role of exogenous and endogenous intestinal alkaline phosphatase in exeperimental colitis of high fat fed mice; sponsored by National Science Centre in Poland (2015/19/B/NZ4/03130 (OPUS)); budget: approx. 700 000 PLN; 2016- in progress; PI: Prof. Tomasz Brzozowski
10. Carbon monoxide (CO) as a physiological gastroprotective factor and modulator of hydrogen sulfide (H2S) sythesis pathways in experimental gastric mucosal damage induced by aspirin; sponsored by National Science Centre in Poland (2014/15/N/NZ4/04564 (PRELUDIUM)); budget: approx. 70 000 PLN; duration: 2015-2017; PI: dr. Marcin Magierowski

…and many other projects financed by statutory grants from the Ministry of Science and Higher Education and Jagiellonian University Medical College.