Scientific publications related to gaseous mediators:
Głowacka U, Magierowski M. Decoding visceral pain: Molecular pathways and translational targets in gaseous signalling and pharmacology. Br J Pharmacol. 2026 Jun 7. doi: 10.1111/bph.70526. Epub ahead of print. PMID: 42252269.
DOI: 10.1111/bph.70526
Korbut E, Wierdak M, Vignane T, Bakalarz D, Magierowska K, Suski M, Janmaat VT, Hankus J, Glowacka U, Farbaniec M, Wójcik-Grzybek D, Whiteman M, Kukla M, Smits R, Souza RF, Filipovic MR, Magierowski M. Pathology-driven epithelial sulfide loss reprograms the redox proteome and triggers Barrett’s esophagus. Gastroenterology. 2026 Jun 2:S0016-5085(26)06937-4. Epub ahead of print. PMID: 42235802. DOI: 10.1053/j.gastro.2026.05.016
Korbut E, Lasota M, Jankowski D, Szeleszczuk Ł, Magierowski M. Hydrogen sulfide and carbon monoxide as possible regulators of YY1 and RKIP: Novel insights into gastrointestinal cancers pathogenesis. Biochim Biophys Acta Rev Cancer. 2025 Oct;1880(5):189448. doi: 10.1016/j.bbcan.2025.189448. Epub 2025 Sep 9. PMID: 40935296. DOI: 10.1016/j.bbcan.2025.189448
Danielak A, Magierowski M. Obesity and mitochondrial uncoupling – an opportunity for the carbon monoxide-based pharmacology of metabolic diseases. Pharmacol Res. 2025 May;215:107741. doi: 10.1016/j.phrs.2025.107741. Epub 2025 Apr 17. PMID: 40252782.
DOI: 10.1016/j.phrs.2025.107741
Korbut E, Suski M, Śliwowski Z, Bakalarz D, Głowacka U, Wójcik-Grzybek D, Ginter G, Krukowska K, Brzozowski T, Magierowski M, Wallace JL, Magierowska K. Physiological healing of chronic gastric ulcer is not impaired by the hydrogen sulphide (H2S)-releasing derivative of acetylsalicylic acid (ATB-340): functional and proteomic approaches. Inflammopharmacology. 2024 Jun;32(3):2049-2060. doi: 10.1007/s10787-024-01458-3. Epub 2024 Apr 3. PMID: 38570398. DOI: 10.1007/s10787-024-01458-3
Magierowska K, Wójcik-Grzybek D, Korbut E, Bakalarz D, Ginter G, Danielak A, Kwiecień S, Chmura A, Torregrossa R, Whiteman M, Magierowski M. The mitochondria-targeted sulfide delivery molecule attenuates drugs-induced gastropathy. Involvement of heme oxygenase pathway. Redox Biol. 2023 Oct;66:102847. doi: 10.1016/j.redox.2023.102847. Epub 2023 Aug 12. PMID: 37597422; PMCID: PMC10458696.
DOI: 10.1016/j.redox.2023.102847
Głowacka U, Magierowski M, Śliwowski Z, Cieszkowski J, Szetela M, Wójcik-Grzybek D, Chmura A, Brzozowski T, Wallace JL, Magierowska K. Hydrogen Sulfide-Releasing Indomethacin-Derivative (ATB-344) Prevents the Development of Oxidative Gastric Mucosal Injuries. Antioxidants (Basel). 2023 Aug 2;12(8):1545. doi: 10.3390/antiox12081545. PMID: 37627540; PMCID: PMC10452022. DOI: 10.3390/antiox12081545
Magierowska K, Korbut E, Wójcik-Grzybek D, Bakalarz D, Sliwowski Z, Cieszkowski J, Szetela M, Torregrossa R, Whiteman M, Magierowski M. Mitochondria-targeted hydrogen sulfide donors versus acute oxidative gastric mucosal injury. J Control Release. 2022 Aug;348:321-334. doi: 10.1016/j.jconrel.2022.05.051. Epub 2022 Jun 8. PMID: 35654168. DOI: 10.1016/j.jconrel.2022.05.051
Krukowska K, Magierowski M. Carbon monoxide (CO)/heme oxygenase (HO)-1 in gastrointestinal tumors pathophysiology and pharmacology – possible anti- and pro-cancer activities. Biochem Pharmacol. 2022 Jul;201:115058. doi: 10.1016/j.bcp.2022.115058. Epub 2022 Apr 28. PMID: 35490732. DOI: 10.1016/j.bcp.2022.115058
Głowacka U, Magierowska K, Wójcik D, Hankus J, Szetela M, Cieszkowski J, Korbut E, Danielak A, Surmiak M, Chmura A, Wallace JL, Magierowski M. Microbiome Profile and Molecular Pathways Alterations in Gastrointestinal Tract by Hydrogen Sulfide-Releasing Nonsteroidal Anti-Inflammatory Drug (ATB-352): Insight into Possible Safer Polypharmacy. Antioxid Redox Signal. 2022 Feb;36(4-6):189-210. doi: 10.1089/ars.2020.8240. Epub 2021 Apr 12. PMID: 33678013. DOI: 10.1089/ars.2020.8240
Bakalarz D, Korbut E, Yuan Z, Yu B, Wójcik D, Danielak A, Magierowska K, Kwiecień S, Brzozowski T, Marcinkowska M, Wang B, Magierowski M. Novel Hydrogen Sulfide (H2S)-Releasing BW-HS-101 and Its Non-H2S Releasing Derivative in Modulation of Microscopic and Molecular Parameters of Gastric Mucosal Barrier. Int J Mol Sci. 2021 May 14;22(10):5211. doi: 10.3390/ijms22105211. PMID: 34069086; PMCID: PMC8155842. DOI: 10.3390/ijms22105211
Danielak A, Wallace JL, Brzozowski T, Magierowski M. Gaseous Mediators as a Key Molecular Targets for the Development of Gastrointestinal-Safe Anti-Inflammatory Pharmacology. Front Pharmacol. 2021 Apr 29;12:657457. doi: 10.3389/fphar.2021.657457. PMID: 33995080; PMCID: PMC8116801. DOI: 10.3389/fphar.2021.657457
Bakalarz D, Surmiak M, Yang X, Wójcik D, Korbut E, Śliwowski Z, Ginter G, Buszewicz G, Brzozowski T, Cieszkowski J, Głowacka U, Magierowska K, Pan Z, Wang B, Magierowski M. Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage. Acta Pharm Sin B. 2021 Feb;11(2):456-475. doi: 10.1016/j.apsb.2020.08.005. Epub 2020 Aug 24. PMID: 33643824; PMCID: PMC7893125. DOI: 10.1016/j.apsb.2020.08.005
Hopper CP, De La Cruz LK, Lyles KV, Wareham LK, Gilbert JA, Eichenbaum Z, Magierowski M, Poole RK, Wollborn J, Wang B. Role of Carbon Monoxide in Host-Gut Microbiome Communication. Chem Rev. 2020 Dec 23;120(24):13273-13311. doi: 10.1021/acs.chemrev.0c00586. Epub 2020 Oct 22. PMID: 33089988. DOI: 10.1021/acs.chemrev.0c00586
Korbut E, Janmaat VT, Wierdak M, Hankus J, Wójcik D, Surmiak M, Magierowska K, Brzozowski T, Peppelenbosch MP, Magierowski M. Molecular Profile of Barrett’s Esophagus and Gastroesophageal Reflux Disease in the Development of Translational Physiological and Pharmacological Studies. Int J Mol Sci. 2020 Sep 3;21(17):6436. doi: 10.3390/ijms21176436. PMID: 32899384; PMCID: PMC7504401. DOI: 10.3390/ijms21176436
Magierowska K, Bakalarz D, Wójcik D, Korbut E, Danielak A, Głowacka U, Pajdo R, Buszewicz G, Ginter G, Surmiak M, Kwiecień S, Chmura A, Magierowski M, Brzozowski T. Evidence for Cytoprotective Effect of Carbon Monoxide Donor in the Development of Acute Esophagitis Leading to Acute Esophageal Epithelium Lesions. Cells. 2020 May 12;9(5):1203. doi: 10.3390/cells9051203. PMID: 32408627; PMCID: PMC7291282. DOI: 10.3390/cells9051203
Korbut E, Brzozowski T, Magierowski M. Carbon Monoxide Being Hydrogen Sulfide and Nitric Oxide Molecular Sibling, as Endogenous and Exogenous Modulator of Oxidative Stress and Antioxidative Mechanisms in the Digestive System. Oxid Med Cell Longev. 2020 Apr 15;2020:5083876. doi: 10.1155/2020/5083876. PMID: 32377300; PMCID: PMC7180415. DOI: 10.1155/2020/5083876
Głowacka U, Brzozowski T, Magierowski M. Synergisms, Discrepancies and Interactions between Hydrogen Sulfide and Carbon Monoxide in the Gastrointestinal and Digestive System Physiology, Pathophysiology and Pharmacology. Biomolecules. 2020 Mar 13;10(3):445. doi: 10.3390/biom10030445. PMID: 32183095; PMCID: PMC7175135. DOI: 10.3390/biom10030445
Magierowska K, Korbut E, Hubalewska-Mazgaj M, Surmiak M, Chmura A, Bakalarz D, Buszewicz G, Wójcik D, Śliwowski Z, Ginter G, Gromowski T, Kwiecień S, Brzozowski T, Magierowski M. Oxidative gastric mucosal damage induced by ischemia/reperfusion and the mechanisms of its prevention by carbon monoxide-releasing tricarbonyldichlororuthenium (II) dimer. Free Radic Biol Med. 2019 Dec;145:198-208. doi: 10.1016/j.freeradbiomed.2019.09.032. Epub 2019 Sep 27. PMID: 31568823. DOI: 10.1016/j.freeradbiomed.2019.09.032
Magierowska K, Bakalarz D, Wójcik D, Chmura A, Hubalewska-Mazgaj M, Licholai S, Korbut E, Kwiecien S, Sliwowski Z, Ginter G, Brzozowski T, Magierowski M. Time-dependent course of gastric ulcer healing and molecular markers profile modulated by increased gastric mucosal content of carbon monoxide released from its pharmacological donor. Biochem Pharmacol. 2019 May;163:71-83. doi: 10.1016/j.bcp.2019.02.011. Epub 2019 Feb 10. PMID: 30753813. DOI: 10.1016/j.bcp.2019.02.011
Magierowska K, Wojcik D, Chmura A, Bakalarz D, Wierdak M, Kwiecien S, Sliwowski Z, Brzozowski T, Magierowski M. Alterations in Gastric Mucosal Expression of Calcitonin Gene-Related Peptides, Vanilloid Receptors, and Heme Oxygenase-1 Mediate Gastroprotective Action of Carbon Monoxide against Ethanol-Induced Gastric Mucosal Lesions. Int J Mol Sci. 2018 Sep 28;19(10):2960. doi: 10.3390/ijms19102960. PMID: 30274172; PMCID: PMC6213448. DOI: 10.3390/ijms19102960
Magierowska K, Brzozowski T, Magierowski M. Emerging role of carbon monoxide in regulation of cellular pathways and in the maintenance of gastric mucosal integrity. Pharmacol Res. 2018 Mar;129:56-64. doi: 10.1016/j.phrs.2018.01.008. Epub 2018 Jan 31. PMID: 29360501. DOI: 10.1016/j.phrs.2018.01.008
Magierowski M, Hubalewska-Mazgaj M, Magierowska K, Wojcik D, Sliwowski Z, Kwiecien S, Brzozowski T. Nitric oxide, afferent sensory nerves, and antioxidative enzymes in the mechanism of protection mediated by tricarbonyldichlororuthenium(II) dimer and sodium hydrosulfide against aspirin-induced gastric damage. J Gastroenterol. 2018 Jan;53(1):52-63. doi: 10.1007/s00535-017-1323-4. Epub 2017 Feb 25. PMID: 28238019. DOI: 10.1007/s00535-017-1323-4
Magierowski M, Magierowska K, Hubalewska-Mazgaj M, Surmiak M, Sliwowski Z, Wierdak M, Kwiecien S, Chmura A, Brzozowski T. Cross-talk between hydrogen sulfide and carbon monoxide in the mechanism of experimental gastric ulcers healing, regulation of gastric blood flow and accompanying inflammation. Biochem Pharmacol. 2018 Mar;149:131-142. doi: 10.1016/j.bcp.2017.11.020. Epub 2017 Dec 1. PMID: 29203367. DOI: 10.1016/j.bcp.2017.11.020
Magierowski M, Magierowska K, Hubalewska-Mazgaj M, Sliwowski Z, Ginter G, Pajdo R, Chmura A, Kwiecien S, Brzozowski T. Carbon monoxide released from its pharmacological donor, tricarbonyldichlororuthenium (II) dimer, accelerates the healing of pre-existing gastric ulcers. Br J Pharmacol. 2017 Oct;174(20):3654-3668. doi: 10.1111/bph.13968. Epub 2017 Aug 30. PMID: 28768046; PMCID: PMC5610153. DOI: 10.1111/bph.13968
Magierowski M, Magierowska K, Surmiak M, Hubalewska-Mazgaj M, Kwiecien S, Wallace JL, Brzozowski T. The effect of hydrogen sulfide-releasing naproxen (ATB-346) versus naproxen on formation of stress-induced gastric lesions, the regulation of systemic inflammation, hypoxia and alterations in gastric microcirculation. J Physiol Pharmacol. 2017 Oct;68(5):749-756. PMID: 29375050. https://www.jpp.krakow.pl/journal/archive/10_17/articles/12_article.html
Magierowski M, Magierowska K, Hubalewska-Mazgaj M, Sliwowski Z, Pajdo R, Ginter G, Kwiecien S, Brzozowski T. Exogenous and Endogenous Hydrogen Sulfide Protects Gastric Mucosa against the Formation and Time-Dependent Development of Ischemia/Reperfusion-Induced Acute Lesions Progressing into Deeper Ulcerations. Molecules. 2017 Feb 15;22(2):295. doi: 10.3390/molecules22020295. PMID: 28212299; PMCID: PMC6155792. DOI: 10.3390/molecules22020295
Bronowicka-Adamska P, Wróbel M, Magierowski M, Magierowska K, Kwiecień S, Brzozowski T. Hydrogen Sulphide Production in Healthy and Ulcerated Gastric Mucosa of Rats. Molecules. 2017 Mar 27;22(4):530. doi: 10.3390/molecules22040530. PMID: 28346391; PMCID: PMC6154691. DOI: 10.3390/molecules22040530
Magierowski M, Magierowska K, Hubalewska-Mazgaj M, Adamski J, Bakalarz D, Sliwowski Z, Pajdo R, Kwiecien S, Brzozowski T. Interaction between endogenous carbon monoxide and hydrogen sulfide in the mechanism of gastroprotection against acute aspirin-induced gastric damage. Pharmacol Res. 2016 Dec;114:235-250. doi: 10.1016/j.phrs.2016.11.001. Epub 2016 Nov 5. PMID: 27825819. DOI: 10.1016/j.phrs.2016.11.001
Magierowski M, Magierowska K, Szmyd J, Surmiak M, Sliwowski Z, Kwiecien S, Brzozowski T. Hydrogen Sulfide and Carbon Monoxide Protect Gastric Mucosa Compromised by Mild Stress Against Alendronate Injury. Dig Dis Sci. 2016 Nov;61(11):3176-3189. doi: 10.1007/s10620-016-4280-5. Epub 2016 Aug 19. PMID: 27541924; PMCID: PMC5067292. DOI: 10.1007/s10620-016-4280-5
Kwiecien S, Magierowska K, Magierowski M, Surmiak M, Hubalewska-Mazgaj M, Pajdo R, Sliwowski Z, Chmura A, Wojcik D, Brzozowski T. Role of sensory afferent nerves, lipid peroxidation and antioxidative enzymes in the carbon monoxide-induced gastroprotection against stress ulcerogenesis. J Physiol Pharmacol. 2016 Oct;67(5):717-729. PMID: 28011952. https://www.jpp.krakow.pl/journal/archive/10_16/articles/09_article.html
Magierowska K, Magierowski M, Surmiak M, Adamski J, Mazur-Bialy AI, Pajdo R, Sliwowski Z, Kwiecien S, Brzozowski T. The Protective Role of Carbon Monoxide (CO) Produced by Heme Oxygenases and Derived from the CO-Releasing Molecule CORM-2 in the Pathogenesis of Stress-Induced Gastric Lesions: Evidence for Non-Involvement of Nitric Oxide (NO). Int J Mol Sci. 2016 Mar 24;17(4):442. doi: 10.3390/ijms17040442. PMID: 27023525; PMCID: PMC4848898. DOI: 10.3390/ijms17040442
Magierowska K, Magierowski M, Hubalewska-Mazgaj M, Adamski J, Surmiak M, Sliwowski Z, Kwiecien S, Brzozowski T. Carbon Monoxide (CO) Released from Tricarbonyldichlororuthenium (II) Dimer (CORM-2) in Gastroprotection against Experimental Ethanol-Induced Gastric Damage. PLoS One. 2015 Oct 13;10(10):e0140493. doi: 10.1371/journal.pone.0140493. PMID: 26460608; PMCID: PMC4604159. DOI: 10.1371/journal.pone.0140493
Magierowski M, Magierowska K, Kwiecien S, Brzozowski T. Gaseous mediators nitric oxide and hydrogen sulfide in the mechanism of gastrointestinal integrity, protection and ulcer healing. Molecules. 2015 May 19;20(5):9099-123. doi: 10.3390/molecules20059099. PMID: 25996214; PMCID: PMC6272495. DOI: 10.3390/molecules20059099
Magierowski M, Jasnos K, Kwiecien S, Drozdowicz D, Surmiak M, Strzalka M, Ptak-Belowska A, Wallace JL, Brzozowski T. Endogenous prostaglandins and afferent sensory nerves in gastroprotective effect of hydrogen sulfide against stress-induced gastric lesions. PLoS One. 2015 Mar 16;10(3):e0118972. doi: 10.1371/journal.pone.0118972. PMID: 25774496; PMCID: PMC4361614. DOI: 10.1371/journal.pone.0118972
Pálinkás Z, Furtmüller PG, Nagy A, Jakopitsch C, Pirker KF, Magierowski M, Jasnos K, Wallace JL, Obinger C, Nagy P. Interactions of hydrogen sulfide with myeloperoxidase. Br J Pharmacol. 2015 Mar;172(6):1516-32. doi: 10.1111/bph.12769. Epub 2014 Sep 5. PMID: 24824874; PMCID: PMC4369261. DOI: 10.1111/bph.12769
Magierowski M, Jasnos K, Sliwowski Z, Surmiak M, Krzysiek-Maczka G, Ptak-Belowska A, Kwiecien S, Brzozowski T. Exogenous asymmetric dimethylarginine (ADMA) in pathogenesis of ischemia-reperfusion-induced gastric lesions: interaction with protective nitric oxide (NO) and calcitonin gene-related peptide (CGRP). Int J Mol Sci. 2014 Mar 20;15(3):4946-64. doi: 10.3390/ijms15034946. PMID: 24658439; PMCID: PMC3975433. DOI: 10.3390/ijms15034946
Jasnos K, Magierowski M, Kwiecień S, Brzozowski T. Tlenek węgla w fizjologii organizmu człowieka–rola w układzie pokarmowym [Carbon monoxide in human physiology–its role in the gastrointestinal tract]. Postepy Hig Med Dosw (Online). 2014 Jan 30;68:101-9. Polish. doi: 10.5604/17322693.1087527. PMID: 24491901. DOI: 10.5604/17322693.1087527
Magierowski M, Jasnos K, Kwiecień S, Brzozowski T. Rola siarkowodoru w fizjologii przewodu pokarmowego i w mechanizmie gastroprotekcji [Role of hydrogen sulfide in the physiology of gastrointestinal tract and in the mechanism of gastroprotection]. Postepy Hig Med Dosw (Online). 2013 Mar 6;67:150-6. Polish. doi: 10.5604/17322693.1038356. PMID: 23475491. DOI: 10.5604/17322693.1038356
Scientific publications related to GI research:
Rzepa A, Wysocki M, Hankus J, Szpor J, Dworak J, Wierdak M, Małczak P, Stefura T, Korbut E, Surmiak M, Magierowski M, Pędziwiatr M, Major P. Impact of Intragastric Balloon Placement on the Stomach Wall: A Prospective Cohort Study. Obes Surg. 2022 Jul;32(7):2426-2432. doi: 10.1007/s11695-022-06101-0. Epub 2022 May 16. PMID: 35576095. DOI: 10.1007/s11695-022-06101-0
Bilski J, Pinkas M, Wojcik-Grzybek D, Magierowski M, Korbut E, Mazur-Bialy A, Krzysiek-Maczka G, Kwiecien S, Magierowska K, Brzozowski T. Role of Obesity, Physical Exercise, Adipose Tissue-Skeletal Muscle Crosstalk and Molecular Advances in Barrett’s Esophagus and Esophageal Adenocarcinoma. Int J Mol Sci. 2022 Apr 1;23(7):3942. doi: 10.3390/ijms23073942. PMID: 35409299; PMCID: PMC8999972. DOI: 10.3390/ijms23073942
Korbut E, Krukowska K, Magierowski M. Barrett’s Metaplasia Progression towards Esophageal Adenocarcinoma: An Attempt to Select a Panel of Molecular Sensors and to Reflect Clinical Alterations by Experimental Models. Int J Mol Sci. 2022 Mar 18;23(6):3312. doi: 10.3390/ijms23063312. PMID: 35328735; PMCID: PMC8955539. DOI: 10.3390/ijms23063312
Wierdak M, Korbut E, Hubalewska-Mazgaj M, Surmiak M, Magierowska K, Wójcik-Grzybek D, Pędziwiatr M, Brzozowski T, Magierowski M. Impact of Vagotomy on Postoperative Weight Loss, Alimentary Intake, and Enterohormone Secretion After Bariatric Surgery in Experimental Translational Models. Obes Surg. 2022 May;32(5):1586-1600. doi: 10.1007/s11695-022-05987-0. Epub 2022 Mar 12. PMID: 35277793. DOI: 10.1007/s11695-022-05987-0
Wojcik-Grzybek D, Hubalewska-Mazgaj M, Surmiak M, Sliwowski Z, Dobrut A, Mlodzinska A, Wojcik A, Kwiecien S, Magierowski M, Mazur-Bialy A, Bilski J, Brzozowski T. The Combination of Intestinal Alkaline Phosphatase Treatment with Moderate Physical Activity Alleviates the Severity of Experimental Colitis in Obese Mice via Modulation of Gut Microbiota, Attenuation of Proinflammatory Cytokines, Oxidative Stress Biomarkers and DNA Oxidative Damage in Colonic Mucosa. Int J Mol Sci. 2022 Mar 9;23(6):2964. doi: 10.3390/ijms23062964. PMID: 35328382; PMCID: PMC8955215. DOI: 10.3390/ijms23062964
Zagajewski J, Wojcik-Grzybek D, Brzozowski B, Majka J, Magierowski M, Placha W, Lasota M, Laidler PM, Brzozowski T. Simultaneous detection of melatonin and six metabolites of L-tryptophan pathway in rat gastric mucosa. J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.15. Epub 2022 Apr 24. PMID: 35485362. DOI: 10.26402/jpp.2021.6.15
Janmaat VT, Nesteruk K, Spaander MCW, Verhaar AP, Yu B, Silva RA, Phillips WA, Magierowski M, van de Winkel A, Stadler HS, Sandoval-Guzmán T, van der Laan LJW, Kuipers EJ, Smits R, Bruno MJ, Fuhler GM, Clemons NJ, Peppelenbosch MP. HOXA13 in etiology and oncogenic potential of Barrett’s esophagus. Nat Commun. 2021 Jun 7;12(1):3354. doi: 10.1038/s41467-021-23641-8. PMID: 34099670; PMCID: PMC8184780. DOI: 10.1038/s41467-021-23641-8
Pacheco G, Oliveira AP, Noleto IRSG, Araújo AK, Lopes ALF, Sousa FBM, Chaves LS, Alves EHP, Vasconcelos DFP, Araujo AR, Nicolau LD, Magierowski M, Medeiros JVR. Activation of transient receptor potential vanilloid channel 4 contributes to the development of ethanol-induced gastric injury in mice. Eur J Pharmacol. 2021 Jul 5;902:174113. doi: 10.1016/j.ejphar.2021.174113. Epub 2021 Apr 24. PMID: 33901460. DOI: 10.1016/j.ejphar.2021.174113
Danielak A, Wojcik D, Mazur-Bialy A, Surmiak M, Bilski J, Targosz A, Magierowski M, Chmura A, Strzalka M, Krzysiek-Maczka G, Magierowska K, Szczyrk U, Kwiecien S, Ptak-Belowska A, Brzozowski T. Intestinal Alkaline Phosphatase Combined with Voluntary Physical Activity Alleviates Experimental Colitis in Obese Mice. Involvement of Oxidative Stress, Myokines, Adipokines and Proinflammatory Biomarkers. Antioxidants (Basel). 2021 Feb 4;10(2):240. doi: 10.3390/antiox10020240. PMID: 33557311; PMCID: PMC7914798. DOI: 10.3390/antiox10020240
Li S, Lavrijsen M, Bakker A, Magierowski M, Magierowska K, Liu P, Wang W, Peppelenbosch MP, Smits R. Commonly observed RNF43 mutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers. Oncogene. 2020 Apr;39(17):3458-3472. doi: 10.1038/s41388-020-1232-5. Epub 2020 Feb 26. PMID: 32103169. DOI: 10.1038/s41388-020-1232-5
Konturek PC, Konturek K, Brzozowski T, Wojcik D, Magierowski M, Targosz A, Krzysiek-Maczka G, Sliwowski Z, Strzalka M, Magierowska K, Szczyrk U, Kwiecien S, Ptak-Belowska A, Neurath M, Dieterich W, Wirtz S, Zopf Y. Participation of the intestinal microbiota in the mechanism of beneficial effect of treatment with synbiotic Syngut on experimental colitis under stress conditions. J Physiol Pharmacol. 2020 Jun;71(3). doi: 10.26402/jpp.2020.3.03. Epub 2020 Sep 26. PMID: 32991312. DOI: 10.26402/jpp.2020.3.03
Bilski J, Wojcik D, Danielak A, Mazur-Bialy A, Magierowski M, Tønnesen K, Brzozowski B, Surmiak M, Magierowska K, Pajdo R, Ptak-Belowska A, Brzozowski T. Alternative Therapy in the Prevention of Experimental and Clinical Inflammatory Bowel Disease. Impact of Regular Physical Activity, Intestinal Alkaline Phosphatase and Herbal Products. Curr Pharm Des. 2020;26(25):2936-2950. doi: 10.2174/1381612826666200427090127. PMID: 32338209. DOI: 10.2174/1381612826666200427090127
Majka J, Wierdak M, Szlachcic A, Magierowski M, Targosz A, Urbanczyk K, Krzysiek-Maczka G, Ptak-Belowska A, Bakalarz D, Magierowska K, Chmura A, Brzozowski T. Interaction of epidermal growth factor with COX-2 products and peroxisome proliferator-activated receptor-γ system in experimental rat Barrett’s esophagus. Am J Physiol Gastrointest Liver Physiol. 2020 Mar 1;318(3):G375-G389. doi: 10.1152/ajpgi.00410.2018. Epub 2020 Jan 13. PMID: 31928220. DOI: 10.1152/ajpgi.00410.2018
Bilski J, Mazur-Bialy A, Wojcik D, Surmiak M, Magierowski M, Sliwowski Z, Pajdo R, Kwiecien S, Danielak A, Ptak-Belowska A, Brzozowski T. Role of Obesity, Mesenteric Adipose Tissue, and Adipokines in Inflammatory Bowel Diseases. Biomolecules. 2019 Nov 26;9(12):780. doi: 10.3390/biom9120780. PMID: 31779136; PMCID: PMC6995528. DOI: 10.3390/biom9120780
Bilski J, Mazur-Bialy A, Wojcik D, Magierowski M, Surmiak M, Kwiecien S, Magierowska K, Hubalewska-Mazgaj M, Sliwowski Z, Brzozowski T. Effect of Forced Physical Activity on the Severity of Experimental Colitis in Normal Weight and Obese Mice. Involvement of Oxidative Stress and Proinflammatory Biomarkers. Nutrients. 2019 May 21;11(5):1127. doi: 10.3390/nu11051127. PMID: 31117199; PMCID: PMC6567060. DOI: 10.3390/nu11051127
Kwiecien S, Magierowski M, Majka J, Ptak-Belowska A, Wojcik D, Sliwowski Z, Magierowska K, Brzozowski T. Curcumin: A Potent Protectant against Esophageal and Gastric Disorders. Int J Mol Sci. 2019 Mar 24;20(6):1477. doi: 10.3390/ijms20061477. PMID: 30909623; PMCID: PMC6471759. DOI: 10.3390/ijms20061477
Majka J, Wierdak M, Brzozowska I, Magierowski M, Szlachcic A, Wojcik D, Kwiecien S, Magierowska K, Zagajewski J, Brzozowski T. Melatonin in Prevention of the Sequence from Reflux Esophagitis to Barrett’s Esophagus and Esophageal Adenocarcinoma: Experimental and Clinical Perspectives. Int J Mol Sci. 2018 Jul 13;19(7):2033. doi: 10.3390/ijms19072033. PMID: 30011784; PMCID: PMC6073539. DOI: 10.3390/ijms19072033
Bilski J, Mazur-Bialy A, Magierowski M, Kwiecien S, Wojcik D, Ptak-Belowska A, Surmiak M, Targosz A, Magierowska K, Brzozowski T. Exploiting Significance of Physical Exercise in Prevention of Gastrointestinal Disorders. Curr Pharm Des. 2018;24(18):1916-1925. doi: 10.2174/1381612824666180522103759. PMID: 29788876. DOI: 10.2174/1381612824666180522103759
Czekaj R, Majka J, Magierowska K, Sliwowski Z, Magierowski M, Pajdo R, Ptak-Belowska A, Surmiak M, Kwiecien S, Brzozowski T. Mechanisms of curcumin-induced gastroprotection against ethanol-induced gastric mucosal lesions. J Gastroenterol. 2018 May;53(5):618-630. doi: 10.1007/s00535-017-1385-3. Epub 2017 Aug 30. PMID: 28856444; PMCID: PMC5910495. DOI: 10.1007/s00535-017-1385-3
Mazur-Bialy AI, Bilski J, Wojcik D, Brzozowski B, Surmiak M, Hubalewska-Mazgaj M, Chmura A, Magierowski M, Magierowska K, Mach T, Brzozowski T. Beneficial Effect of Voluntary Exercise on Experimental Colitis in Mice Fed a High-Fat Diet: The Role of Irisin, Adiponectin and Proinflammatory Biomarkers. Nutrients. 2017 Apr 20;9(4):410. doi: 10.3390/nu9040410. PMID: 28425943; PMCID: PMC5409749. DOI: 10.3390/nu9040410
Bilski J, Mazur-Bialy A, Wojcik D, Zahradnik-Bilska J, Brzozowski B, Magierowski M, Mach T, Magierowska K, Brzozowski T. The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract. Mediators Inflamm. 2017;2017:9074601. doi: 10.1155/2017/9074601. Epub 2017 Feb 21. PMID: 28316376; PMCID: PMC5339520. DOI: 10.1155/2017/9074601
Brzozowski T, Magierowska K, Magierowski M, Ptak-Belowska A, Pajdo R, Kwiecien S, Olszanecki R, Korbut R. Recent Advances in the Gastric Mucosal Protection Against Stress-induced Gastric Lesions. Importance of Renin-angiotensin Vasoactive Metabolites, Gaseous Mediators and Appetite Peptides. Curr Pharm Des. 2017;23(27):3910-3922. doi: 10.2174/1381612823666170220160222. PMID: 28228069. DOI: 10.2174/1381612823666170220160222
Bilski J, Mazur-Bialy A, Brzozowski B, Magierowski M, Zahradnik-Bilska J, Wójcik D, Magierowska K, Kwiecien S, Mach T, Brzozowski T. Can exercise affect the course of inflammatory bowel disease? Experimental and clinical evidence. Pharmacol Rep. 2016 Aug;68(4):827-36. doi: 10.1016/j.pharep.2016.04.009. Epub 2016 May 2. PMID: 27255494. DOI: 10.1016/j.pharep.2016.04.009
Czekaj R, Majka J, Ptak-Belowska A, Szlachcic A, Targosz A, Magierowska K, Strzalka M, Magierowski M, Brzozowski T. Role of curcumin in protection of gastric mucosa against stress-induced gastric mucosal damage. Involvement of hypoacidity, vasoactive mediators and sensory neuropeptides. J Physiol Pharmacol. 2016 Apr;67(2):261-75. PMID: 27226186. https://www.jpp.krakow.pl/journal/archive/04_16/articles/10_article.html
Kwiecień S, Magierowska K, Śliwowski Z, Wójcik D, Magierowski M, Brzozowski T. New insight into the mechanisms of gastroduodenal injury induced by nonsteroidal anti-inflammatory drugs: practical implications. Pol Arch Med Wewn. 2015;125(3):191-8. doi: 10.20452/pamw.2715. Epub 2015 Feb 10. PMID: 25666703. DOI: 10.20452/pamw.2715
Bilski J, Mazur-Bialy AI, Brzozowski B, Magierowski M, Jasnos K, Krzysiek-Maczka G, Urbanczyk K, Ptak-Belowska A, Zwolinska-Wcislo M, Mach T, Brzozowski T. Moderate exercise training attenuates the severity of experimental rodent colitis: the importance of crosstalk between adipose tissue and skeletal muscles. Mediators Inflamm. 2015;2015:605071. doi: 10.1155/2015/605071. Epub 2015 Jan 5. PMID: 25684862; PMCID: PMC4313673. DOI: 10.1155/2015/605071
Kwiecien S, Jasnos K, Magierowski M, Sliwowski Z, Pajdo R, Brzozowski B, Mach T, Wojcik D, Brzozowski T. Lipid peroxidation, reactive oxygen species and antioxidative factors in the pathogenesis of gastric mucosal lesions and mechanism of protection against oxidative stress – induced gastric injury. J Physiol Pharmacol. 2014 Oct;65(5):613-22. PMID: 25371520. https://www.jpp.krakow.pl/journal/archive/10_14/articles/02_article.html
Szlachcic A, Krzysiek-Maczka G, Pajdo R, Targosz A, Magierowski M, Jasnos K, Drozdowicz D, Kwiecien S, Brzozowski T. The impact of asymmetric dimethylarginine (ADAMA), the endogenous nitric oxide (NO) synthase inhibitor, to the pathogenesis of gastric mucosal damage. Curr Pharm Des. 2013;19(1):90-7. doi: 10.2174/13816128130113. PMID: 22950506. DOI: 10.2174/13816128130113
Magierowski M, Jasnos K, Brzozowska I, Drozdowicz D, Sliwowski Z, Nawrot E, Szczyrk U, Kwiecień S. Melatonina jako czynnik leczniczy wzgledem wrzodów zoładka w warunkach eksperymentalnej cukrzycy [Melatonin as a therapeutic factor in gastric ulcer healing under experimental diabetes]. Przegl Lek. 2013;70(11):942-6. Polish. PMID: 24697035.
Kwiecien S, Ptak-Belowska A, Krzysiek-Maczka G, Targosz A, Jasnos K, Magierowski M, Szczyrk U, Brzozowski B, Konturek SJ, Konturek PC, Brzozowski T. Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, interacts with gastric oxidative metabolism and enhances stress-induced gastric lesions. J Physiol Pharmacol. 2012 Oct;63(5):515-24. PMID: 23211305. https://www.jpp.krakow.pl/journal/archive/10_12/articles/09_article.html
Kwiecien S, Konturek PC, Sliwowski Z, Mitis-Musiol M, Pawlik MW, Brzozowski B, Jasnos K, Magierowski M, Konturek SJ, Brzozowski T. Interaction between selective cyclooxygenase inhibitors and capsaicin-sensitive afferent sensory nerves in pathogenesis of stress-induced gastric lesions. Role of oxidative stress. J Physiol Pharmacol. 2012 Apr;63(2):143-51. PMID: 22653901. https://www.jpp.krakow.pl/journal/archive/04_12/articles/06_article.html
Gaseous Mediators and Experimental Gastroenterology Laboratory
Center for Biomedicine and Interdisciplinary Sciences ul. Grzegórzecka 16, 31-531 Kraków Tel.: +48126199640 E-mail: m.magierowski@uj.edu.pl
Gaseous Mediators and Experimental Gastroenterology Laboratory
Center for Biomedicine and Interdisciplinary Sciences ul. Grzegórzecka 16, 31-531 Kraków Tel.: +48126199640 E-mail: m.magierowski@uj.edu.pl
Gaseous Mediators and Experimental Gastroenterology Laboratory
Center for Biomedicine and Interdisciplinary Sciences ul. Grzegórzecka 16, 31-531 Kraków Tel.: +48126199640 E-mail: m.magierowski@uj.edu.pl
Gaseous Mediators and Experimental Gastroenterology Laboratory
Center for Biomedicine and Interdisciplinary Sciences ul. Grzegórzecka 16, 31-531 Kraków Tel.: +48126199640 E-mail: m.magierowski@uj.edu.pl
Gaseous Mediators and Experimental Gastroenterology Laboratory
Center for Biomedicine and Interdisciplinary Sciences ul. Grzegórzecka 16, 31-531 Kraków Tel.: +48126199640 E-mail: m.magierowski@uj.edu.pl