GaMEG lab is a research group leaded by prof. Marcin Magierowski, focused on the physiology, pathophysiology and pharmacology of gastrointestinal (GI) tract and GI disorders. We are especially interested in the possible implementation of endogenous gaseous mediators-releasing compounds into the GI pharmacology. We work on experimental in vitro and in vivo models using human-derived cell lines and laboratory animals. GaMEG lab is also establishing collaboration with clinically-oriented departments within Jagiellonian University.

GaMEG lab is settled in Center for Biomedicine and Interdisciplinary Sciences (pol. Ośrodek Biomedycyny i Nauk Interdyscyplinarnych) with the Genetic Engineering Laboratory (GMM, class II) status and lab-animal facility no. 1 located at the Faculty of Medicine, Jagiellonian University Medical College, crucial for our scientific activity.

GaMEG lab is/has been involved in few research grants:

1. Development of the DRUG-PREDICT technology for preclinical prediction of the clinical efficacy of biologically active compounds in colorectal and pancreatic cancer indications, based on translational in vitro and in vivo preclinical models supported by ML tools enabling the identification of the best innovative drug candidates and optimal patient groups; joint project by the Jagiellonian University Medical College (UJ CM) and Selvita, selected for funding under the European Funds for a Modern Economy (FENG.01.01-IP.01-A0Y3/25-00), the “SMART Path” competition (FENG.01.01-IP.01-003/24) organized by the National Centre for Research and Development (NCBR), budget: approx. for UJ CM: 6 249 715 PLN (total: 18 971 451,12 PLN); duration: 2026-present; PI: prof. Marcin Magierowski
   https://gameg.cm-uj.krakow.pl/projekt-drug-predict/
2. Raman spectroscopy guided assessment of vascular niche microenvironment influence on leukemic myeloid progenitors and leukemia treatment effectiveness; sponsored by National Science Centre in Poland, OPUS (651624/OPUS 29/NZ5/00713) ; budget: approx. 1 999 409 PLN; duration: 2025-present; PI: dr Adriana Adamczyk
3. Targeted Cellular Signaling of Hydrogen Sulfide Molecules as the Missing Key to the Fundamental and Clinical Interpretation of Esophageal Disorders; sponsored by National Science Centre in Poland, Sonata Bis (2023/50/E/NZ4/00360); budget: approx. 5 499 000 PLN; duration: 2025-present; PI: prof. Marcin Magierowski
4. Therapeutic potential of a new CO-releasing prodrug in the healing of chronic gastric ulcers; sponsored by Ministry of Education and Science in Poland (PN/01/0279/2022 (Perły nauki)); budget 239 844,00 PLN in collaboration with Prof. Binghe Wang, Georgia State University (Atlanta, USA), PI:. Msc Aleksandra Danielak (MD, PhD student), Supervisor: prof. Marcin Magierowski
5. Endogenous carbon monoxide (CO) and novel CO-releasing prodrugs in pathophysiology and pharmacology of esophageal metaplasia development; sponsored by National Science Centre in Poland (2019/33/B/NZ4/00616 (OPUS)); budget: approx. 2 350 000 PLN; scientific partners: i) Prof. Binghe Wang, Georgia State University (Atlanta, USA), ii) Laboratory of Gastroenterology and Hepatology, Erasmus MC (The Netherlands); duration: 2020-present; PI: dr. Marcin Magierowski
6. Modulation of molecular pathways by pharmacological mitochondria-targeting hydrogen sulfide donor in chronic gastric ulcer healing process; sponsored by National Science Centre in Poland (2020/37/N/NZ4/04192 (PRELUDIUM)); budget: approx. 210 000 PLN; scientific partner: Prof. Matthew Whiteman, University of Exeter (The United Kingdom); duration: 2021-present, PI: dr. Dagmara Wójcik, Supervisor: dr. Marcin Magierowski
7. The role of the physical exercise and skeletal muscle-adipose tissue crosstalk in the development of experimental Barrett’s esophagus and esophageal adenocarcinoma; sponsored by National Science Centre in Poland (2020/37/B/NZ4/03454 (OPUS)); budget: approx. 2 200 000 PLN; duration: 2021-present, PI: Prof. Tomasz Brzozowski
8. Novel hydrogen sulfide-releasing derivatives of non-steroidal anti-inflammatory drugs in the treatment and prevention of esophageal mucosa disorders; sponsored by The National Center for Research and Development (0055/L-8/2016 (LIDER)); budget: approx. 1 200 000 PLN; bussiness partner: Antibe Therapeutics Inc., Toronto (Canada); duration: 2018- 2022; PI: dr. Marcin Magierowski
9. Hydrogen sulfide as endogenous protective molecule in pathophysiology of Barrett’s esophagus development; sponsored by National Science Centre in Poland (2014/15/N/NZ4/04564 (SONATA)); budget: approx. 850 000 PLN; scientific partner: Laboratory of Gastroenterology and Hepatology, Erasmus MC (The Netherlands); duration: 2017-2022; PI: dr. Marcin Magierowski
10. The influence of bariatric surgery procedures and vagotomy on changes to the secretion of gastrointestinal hormones associated with obesity and the degree of weight loss – an animal model experimental study; sponsored by National Science Centre in Poland (2016/23/N/NZ4/03252 (PRELUDIUM)); budget: approx. 50 000 PLN; duration: 2017-2019; PI: dr. Mateusz Wierdak
11. Involvement of carbon monoxide (CO) in gastroprotection against experimental ischemia/reperfusion-induced gastric erosions; sponsored by National Science Centre in Poland (2016/23/N/NZ4/01890 (PRELUDIUM));  budget: approx. 50 000 PLN; duration: 2017-2019; PI: dr. Katarzyna Magierowska
12. Role of mesenteric white adipose tissue and muscle-fat crosstalk on severity of experimental colitis in mice; sponsored by National Science Centre in Poland (2013/09/B/NZ4/01566 (OPUS)); budget: approx. 600 000 PLN; duration: 2014-2018; PI: Prof. Tomasz Brzozowski
13. Role of exogenous and endogenous intestinal alkaline phosphatase in exeperimental colitis of high fat fed mice; sponsored by National Science Centre in Poland (2015/19/B/NZ4/03130 (OPUS)); budget: approx. 700 000 PLN; 2016- 2020; PI: Prof. Tomasz Brzozowski
14. Carbon monoxide (CO) as a physiological gastroprotective factor and modulator of hydrogen sulfide (H2S) sythesis pathways in experimental gastric mucosal damage induced by aspirin; sponsored by National Science Centre in Poland (2014/15/N/NZ4/04564 (PRELUDIUM)); budget: approx. 70 000 PLN; duration: 2015-2017; PI: dr. Marcin Magierowski

…and many other projects financed by statutory grants from the Ministry of Science and Higher Education and Jagiellonian University Medical College.